Background: Smart biomaterials are emerging as advanced alternatives to conventional orthopedic implant materials due to their ability to actively interact with biological environments and promote bone healing.
Objective: To evaluate the role of smart biomaterials in improving orthopedic implant performance and bone regeneration.
Methods: A comparative review of six smart biomaterial categories was conducted using published experimental, preclinical, and clinical studies, assessing osseointegration, mechanical strength, regeneration efficiency, and biocompatibility.
Results: Smart biomaterials showed improved clinical outcomes compared with conventional materials, including higher osseointegration (91% vs. 71%), enhanced bone regeneration (85% vs. 62%), increased implant survival, and reduced corrosion rates. Titanium alloys demonstrated superior mechanical strength, while bioglass and PLGA composites exhibited greater regenerative potential.
Conclusion: Smart biomaterials significantly enhance orthopedic implant performance and represent a promising strategy for next-generation regenerative orthopedic applications.