The integration of three-dimensional imaging technologies has fundamentally transformed diagnostic accuracy and treatment planning capabilities in orthopedic and orthodontic practice. This review synthesizes current evidence on innovations in 3D imaging for integrated skeletal and dentofacial management, examining cone-beam computed tomography, intraoral scanning, 3D facial scanning, and image fusion technologies within clinical and translational frameworks. The aim is to provide clinicians and researchers with a comprehensive understanding of how these technologies enhance precision in treatment planning, improve outcome predictability, and facilitate interdisciplinary coordination. Key methodological frameworks examined include volumetric analysis of craniofacial structures, spatial relationship assessment, growth evaluation models, and image fusion protocols. Clinical applications are reviewed across orthodontic domains including impacted tooth localization, asymmetry analysis, anchorage planning, and airway assessment, as well as orthopedic applications encompassing skeletal discrepancy evaluation, maxillary expansion planning, and Class II/III growth modification. Virtual surgical planning for orthognathic cases demonstrates particular value in simulating surgical movements, predicting soft tissue outcomes, and guiding intraoperative execution. Comparative evaluation of 2D versus 3D approaches reveals superior diagnostic accuracy with 3D imaging for complex anatomical assessments, though cost-effectiveness and radiation considerations require judicious application following ALARA principles. Implementation strategies emphasize standardized acquisition protocols, integrated digital workflows, and interdisciplinary communication frameworks. Challenges and future directions encompass artificial intelligence in image analysis, predictive outcome modeling, personalized digital orthodontics, and multicenter validation studies. The review concludes that 3D imaging, when appropriately integrated into clinical practice, enables precision treatment planning that optimizes outcomes across the spectrum of orthopedic and orthodontic care.