Adolescent skeletal malocclusions represent a significant proportion of orthodontic cases requiring intervention during active growth periods to achieve optimal functional and esthetic outcomes. This review provides a comparative evaluation of non-surgical orthopedic interventions for adolescent skeletal malocclusions, examining clinical outcomes, biomechanical mechanisms, and translational implementation frameworks. The aim is to synthesize current evidence guiding clinical decision-making across Class II, Class III, transverse, and vertical skeletal discrepancies. Key biomechanical frameworks examined include growth modification timing relative to skeletal maturity, force magnitude and duration characteristics, and the distinction between compliance-dependent and compliance-independent systems. Comparative analysis of clinical applications reveals that functional appliances for Class II correction achieve mandibular length increases of 2-4 mm when utilized during peak growth velocity, while fixed functional appliances eliminate compliance concerns with comparable skeletal effects. Class III management with facemask therapy following maxillary expansion produces maxillary advancements of 2-5 mm, with skeletal anchorage-assisted protraction demonstrating enhanced skeletal effects and reduced dental compensation. Transverse deficiency correction through rapid maxillary expansion achieves suture opening of 4-8 mm in early adolescents, with hybrid expanders extending applicability to older patients. Long-term stability evidence indicates that skeletal changes are maintained when treatment is appropriately timed and retention protocols observed, though relapse potential varies with growth remaining and functional adaptation. Translational implementation frameworks emphasize the importance of systematic case selection, skeletal maturity assessment, multidisciplinary coordination, and standardized outcome monitoring. Challenges and future directions include predictive growth modeling, digital treatment simulation, personalized protocols based on individual growth characteristics, and multicenter trials with standardized outcome measures. The review concludes that evidence-based selection among available orthopedic interventions, guided by individual patient characteristics and implemented within structured clinical frameworks, optimizes outcomes for adolescents with skeletal malocclusions.