The management of craniofacial anomalies represents a complex and significant challenge in orthodontic and craniofacial orthopedic practice, requiring precise diagnosis and highly individualized treatment strategies. Conventional approaches, reliant on two-dimensional radiographs and standardized appliances, often fall short in addressing the intricate three-dimensional (3D) skeletal, dental, and soft tissue discrepancies characteristic of conditions like cleft lip/palate, craniosynostoses, and severe skeletal malocclusions. This review aims to synthesize current advancements and elucidate the clinical and translational frameworks integrating advanced imaging and additive manufacturing technologies into contemporary care. The rationale centers on the paradigm shift towards digital workflows that enhance diagnostic accuracy, enable virtual treatment simulation, and facilitate the fabrication of patient-specific devices. Key methodological frameworks include the utilization of cone-beam computed tomography (CBCT) for 3D skeletal assessment, intraoral and facial scanning for digital dentofacial modeling, and various 3D printing technologies for fabricating customized brackets, aligners, and orthopedic appliances. Major clinical applications span from sophisticated treatment planning for cleft care to the fabrication of custom distraction osteogenesis devices and digitally planned surgical splints for orthognathic surgery. Concluding remarks emphasize that the integration of these technologies fosters more predictable, efficient, and patient-centered outcomes, with future directions pointing towards artificial intelligence-assisted planning and bioactive, smart appliances for truly translational orthodontic innovation.