Nanotechnology is revolutionizing orthopedic implants and orthodontic brackets, offering substantial improvements in bioactivity, antibacterial function, osseointegration, wear resistance, and patient outcomes. This review critically evaluates recent clinical data and emerging trends in the application of nanomaterials to orthopedic prostheses and orthodontic devices. Highlights include improved bone healing, stability, reduced infection rates, and enhanced aesthetics in orthodontics. While numerous preclinical studies validate nano-engineered surfaces and coatings, standardization, long-term safety, and translation to routine clinical practice remain ongoing challenges. Future research will benefit from multi-disciplinary collaboration and continued material innovation.