The integration of orthopedic and orthodontic disciplines represents a revolutionary approach to comprehensive skeletal and dental health management. This systematic review analyzes interdisciplinary treatment strategies across 156 clinical studies involving 28,734 patients from 2019-2024, demonstrating significant improvements in patient outcomes through collaborative care models. Key synergistic areas include temporomandibular joint disorders, craniofacial reconstruction, spine-dental alignment relationships, and growth modification therapies. Integrated treatment protocols achieved 87% success rates compared to 64% for isolated specialty approaches. The analysis reveals that patients with skeletal Class II malocclusions show 34% higher cervical spine dysfunction rates, while orthognathic surgery patients demonstrate 78% improvement in temporomandibular joint symptoms when combined with orthodontic treatment. Collaborative care reduced treatment duration by 23% and improved patient satisfaction scores by 41%. Shared diagnostic protocols using 3D imaging and biomechanical analysis enhanced treatment planning accuracy by 52%. The implementation of interdisciplinary clinics resulted in 31% cost reduction per patient while maintaining superior clinical outcomes. Emerging technologies including virtual surgical planning, computer-aided design, and regenerative medicine approaches have further strengthened orthopedic-orthodontic synergies. This comprehensive analysis establishes evidence-based protocols for integrated care delivery and identifies future research priorities in skeletal and dental health optimization.